講座名稱：Stem Cell Imaging-Bench to Bedside-a 15 Year Journey

講座時間：2019-09-16 14:30:00

講座地點：南校區(qū)G樓118報告廳

講座人：Kishore Bhakoo

講座人介紹：

Kishore Bhakoo教授1978年畢業(yè)于坎特伯雷肯特大學(xué)醫(yī)學(xué)生物化學(xué)專業(yè)。他于1983年獲得倫敦大學(xué)神經(jīng)病學(xué)研究所博士學(xué)位，并在路德維希癌癥研究所完成博士后培訓(xùn)。 1986年，他在倫敦皇家外科醫(yī)學(xué)院和兒童健康研究所任研究員。1996年，他在牛津大學(xué)生物化學(xué)系MRC磁共振光譜學(xué)系擔(dān)任研究講師和職員科學(xué)家。2002年在倫敦帝國理工學(xué)院MRC臨床科學(xué)中心擔(dān)任MRC集團負責(zé)人和高級講師，并成立了干細胞成像小組。2009年，擔(dān)任新加坡生物成像聯(lián)盟（SBIC）的轉(zhuǎn)化分子成像組組長。 2011年，擔(dān)任新成立的翻譯影像工業(yè)實驗室A * STAR的主任。該實驗室直接與工業(yè)界合作，通過成像技術(shù)開發(fā)新藥。

講座內(nèi)容：

Stem cells are currently being evaluated for their therapeutic potential to replace cells in a number of disease or degenerative pathologies. The monitoring of cellular grafts, non-invasively, is an important aspect of the ongoing efficacy and safety assessment of cell-based therapies. Magnetic resonance imaging methods are potentially well suited for such an application, as they produce non-invasive ‘images’ of opaque tissues. For transplanted stem cells to be visualised and tracked by MRI, they need to be tagged so that they are ‘MR visible’. We have developed and implemented a programme of Molecular Imaging in pre-clinical models that is directed towards improving our understanding of in vivo stem cell behaviour in the context of the whole organism.

In order to achieve these goals, we are engineering novel MRI contrast agents and developing specific tagging molecules to deliver efficient amounts of contrast agents into stem cells. The intracellular contrast agents are based on either superparamagnetic nanoparticles, such as polymer-coated iron oxide, or other paramagnetic MR contrast agents.

With its ability to precisely target cell delivery, track cell migration and non-invasively evaluate living subjects over time, this technique will help in the translation and facilitate the clinical realisation and optimisation of stem cell-based therapies. Moreover, it is important that we develop additional multimodal imaging (MRI, PET, SPECT/CT and Optical) methodologies for in vivo monitoring of functional aspects of implanted stem cells.

主辦單位：先進材料與納米科技學(xué)院